A test without a needle or a drop of blood to see if you’ve had the virus before

If Covid-19 leaves our minds, it will never leave the country. He’s seen more than 80,000 people get infected every day in recent weeks. Test centers are running at full speed while researchers are still working on how to improve virus detection and antibody detection methods. Last? A skin patch that allows you to perform a serological test without needles or blood.

The COVID-19 He has never left France since arriving in the territory at the beginning of 2020. Over the past few weeks, variables fromOmicron BA4 and BA5 are actively traded, making it seventh mysterious Epidemic. More than 85,000 daily cases were registered (seven-day average); A number we have not known since the end of April 2022 and the end of the sixth wave. mechanically, examination centers Running at full speed: Every day, more than 300,000 tests are performed (average over seven days).

Japanese researchers presented in article Scientific Reports small device dermatology To determine the presence or absence ofantibody Anti-SARS-CoV-2 without one Drops blood. This will not replace PCR that detects the SARS-CoV-2 genome, but it can be a complementary test that provides a quick result on the patient’s serostatus. In fact, the result can be read in three minutes.

Detection of SARS-CoV-2 antibodies through the skin

The device looks like a bandage stuck to the skin. Scattered with thousands of microscopic porous pricks pumping liquid percutaneous interstitial noodles. The presence of SARS-CoV-2 antibodies is then determined by immunochromatography. Antibodies bind to their RBD antigen (Receptor binding domain). The result, see the chart below, reads like those for antigen tests to be done at home.

If the result is positive for IgM, this indicates a recent infection, on the order of a week, of the tested patient. If the result is positive for both IgM and IgG, then the previous infection was one to three weeks ago, and if the result is only positive for IgG, then the previous infection is old. The sensitivity of the test makes it possible to detect antibody concentrations as low as 3 ng/ml of IgG and 7 ng/ml of Ig M. However, its efficacy has not been tested. PCR remains the reference method for detection COVID-19but if this device meets all the criteria for efficiency and safety, it could be an interesting diagnostic accessory, particularly for identifying primary infections while avoiding the stress and risks associated with blood sampling.

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